麻豆社madou
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Shyam Kumar Mishra (Baishnab)

Shyam Kumar Mishra (Baishnab)

PhD Candidate
Postgraduate Research Student
Medicine & Health
School of Optometry and Vision Science

Research title:听Spectrum and mechanism of action of antimicrobial peptidomimetics against ESKAPEE pathogens and Candida species

Supervisors: Prof. Mark Willcox, Dr. Edgar Hoe Hon Wong, Dr. Alex Hui

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Abstract

Globally, there has been rapid emergence of antimicrobial resistance, contributing to 700,000 patient deaths every year. This situation is expected to worsen in the future with 10 million deaths per year at a cumulative global cost of $100 trillion estimated by 2050. In 2017, the World Health Organization (WHO) published a list of antibiotic-resistant 鈥減riority pathogens鈥 for research and development of new antibiotics including the 鈥淓SKAPE鈥 pathogens: carbapenem resistant Acinetobacter baumannii, multi-drug resistant Pseudomonas aeruginosa, Enterobacteriaceae and others. These microbes are often associated with device-associated infections (DAIs) and are non-responsive to traditional antibiotics.

In medical science, biomaterials are used extensively to augment or restore function, and replace tissue. Antimicrobial coatings of device surfaces are required to prevent bacterial colonisation and DAIs. To address this, one of the strategies is the use of cationic antimicrobial peptides (AMPs) as coatings for biomaterials. However, AMPs are susceptible to proteases found in blood or other body fluids. Therefore, development of mimetics of AMPs resistant to proteases as novel anti-infective agents with increased bioavailability is a promising tool in the scientific arena.

Peptoids are non-natural mimics of polypeptides containing poly-N-substituted glycine residues. My research focuses on immobilisation of peptoids on surfaces, and characterizing their mode of action in preventing microbial colonisation on biomaterials. This research will also explore synergy between these peptoids and available antibiotics to combat extensively drug resistant bacteria.

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Biography

Shyam completed his MS in Medical Laboratory Sciences Microbiology from the Institute of Medicine, Nepal in 2009. For the next ten years he held a lecturing position at the Institute and during this time had the opportunity to work as a foreign guest researcher in the stem cell biology laboratory of Ehime University in Japan. In 2019, Shyam received the 麻豆社madou Scientia PhD scholarship and started his interdisciplinary postgraduate journey under the supervision of Professor Mark Willcox, Dr. Edgar Hoe Hon Wong and Dr. Alex Hui. Shyam鈥檚 PhD project focuses on different aspects of peptoids, particularly their antimicrobial activity against selected microbes.

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Education

Year

Degree

Institution

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Current

PhD Candidate

University of New South Wales, Australia

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2009

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MSc MLT Microbiology

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Institute of Medicine (IOM),

Tribhuvan University (TU), Nepal

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2004

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Bachelor in Medical Laboratory Technology (BMLT)

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IOM, TU,

Nepal

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Awards

2019 - Scientia Scholarship for PhD 鈥 麻豆社madou (Australia)

2018 - Society of Healthcare Epidemiology of America - International Ambassadors Award (USA)

2016 - ASMCUE Leadership grant for international educators for outstanding contribution in Undergraduate Microbiology teaching (USA)

2011 鈥 Nepal Bidya Bhusan Padak 鈥淜HA鈥 award from the President of Nepal for standing first place in Postgraduate education

2009 - Second Best Paper Presentation in Research Conference on Health Science, IOM

2008 鈥 Nepal Bidya Bhusan Padak 鈥淕A鈥 award from the President of Nepal for standing first place in Undergraduate education

1994 鈥 Third place in the ninth National Essay Competition (Nepal Red Cross Society)

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Conference attendance

2019 鈥 European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) - Amsterdam, Netherlands

2018 鈥 Society for Healthcare Epidemiology of American (SHEA) Spring Conference 鈥 Oregon, USA

2018 鈥 American Society for Microbiology (ASM) Microbe 2018, in Atlanta, USA

2018 鈥 Workshop on Advanced bioanalytical methods and applications organized by the Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, India

2016 - American Society for Microbiology Conference for Undergraduate Educators (ASMCUE) - Maryland, USA

2016- 17th International Congress on Infectious Diseases (ICID) - Hyderabad, India

2015 - 10th International Symposium on Antimicrobial agents and resistance (ISAAR) - Incheon, Korea

2014 - 32nd World Congress of Internal Medicine (WCIM) - Seoul, Korea

2012 - 15th International Congress on Infectious Diseases (ICID) in Bangkok, Thailand

2012- 6th Ditan International Conference of Infectious Diseases in Beijing, China.

2008 鈥 5th National Conference on Science and Technology, Kathmandu, Nepal

2004 鈥 1st SAARC Conference on TB, HIV/AIDS and Respiratory Diseases 鈥 Kathmandu, Nepal

2004 - 1st International Conference of Medical Laboratory Sciences - Kathmandu, Nepal

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Affiliations and memberships

Global Alliance for Infections in Surgery (International Advisory Board)

American Society for Microbiology (ASM)

American Society for Clinical Pathology (ASCP)

British Infection Association (BIA)

International Society of Infectious Diseases (ISID)

Nepal Health Professional Council (NHPC)

Nepal Association for Medical Laboratory Sciences (NAMLS)

Nepal Medical Laboratory Students' Society (President, 2006-2007)
Email

s.mishrabaishnab@unsw.edu.au

Publications

    1. Mishra SK, Kuppusamy R, Nguyen C, Doeur J, Atwal H, S酶rensen K, Lin JS, Wong EHH, Hui A, Barron AE, Kumar N, Willcox N, Willcox M. Evaluation of the Synergistic Activity of Antimicrobial Peptidomimetics or Colistin Sulphate with Conventional Antifungals Against Yeasts of Medical Importance. Journal of Fungi. 2025; 11, 370. 听()
    2. Mishra SK, Yasir M, Kuppusamy R, Wong EH, Hui A, S酶rensen K, Lin JS, Jenssen H, Barron AE, Willcox M. Antimicrobial activity of peptoids against Metallo-尾-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris. Journal of Applied Microbiology. 2025 Feb 11:lxaf031. ()
    3. Mishra SK, Akter T, Urmi UL, Enninful G, Sara M, Shen J, Suresh D, Zheng L, Mekonen ES, Rayamajhee B, Labricciosa FM, Sartelli M, Willcox M. Harnessing Non-Antibiotic Strategies to Counter Multidrug-Resistant Clinical Pathogens with Special Reference to Antimicrobial Peptides and Their Coatings. Antibiotics 2025 Jan 9; 14(1):57. ()
    4. Luo H, Shao Z, Hakobyan K, Xu J, Kuchel RP, Mishra SK, Willcox MD, Wong E. 尾-lactamase-activated antimicrobial dendron via the amine uncaging strategy. Chemical Science 2025. (doi:听)
    5. Sah RK, Bhattarai A, Khadka P, Sharma S, Mishra SK, Rai J, Raut S. Current antibiotic resistance profile of ESKAPE pathogens in a Nepalese hospital: A cross-sectional study. Canadian Journal of Infectious Diseases and Medical Microbiology 2025; 2025(1):4426596. ()
    6. Yadav P, Shrestha S, Basyal D, Tiwari A, Sah R, Sah AK, Yadav B, Willcox M, Mishra SK. Characterization and Biofilm Inhibition of Multidrug鈥怰esistant Acinetobacter baumannii Isolates. International Journal of Microbiology 2024;2024(1):5749982. ()
    7. Yadav P, Mishra SK, Shrestha S, Sah R, Rai JR, Kattel HP, Sharma S, Willcox M. Multidrug-resistance and biofilm formation among Acinetobacter baumannii isolated from clinical specimens. Journal of Nepal Health Research Council 22(04), 662-669. ()
    8. Bahatheg G, Kuppusamy R, Yasir M, Bridge S, Mishra SK, Cranfield CG, Black DS, Willcox M, Kumar N. Dimeric peptoids as antibacterial agents. Bioorganic Chemistry 2024;147:107334.
    9. Mishra SK, Baidya S, Bhattarai A, Shrestha S, Homagain S, Rayamajhee B, Hui A, Willcox M. Bacteriology of endotracheal tube biofilms and antibiotic resistance: a systematic review. Journal of Hospital Infection 2024 Mar 22.
    10. Dahal K, Rawal L, Shah S, Pokharel S, Dahal M, Shrestha S, Mishra SK, Maharjan S, Baidya S. Pattern of antibiotic resistance in surgical site infections in a tertiary care hospital of Nepal. IJS Global Health 2024 Mar 1;7(2):e0403
    11. Sartelli M, Barie PS, Coccolini F, 鈥. Mishra SK, 鈥t al. Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action. World Journal of Emergency Surgery, 2023. 18(1): p. 50. () (Role: Literature review, study design, analysis, manuscript preparation, proof reading)
    12. Dahal A, Shrestha K, Karki R, Bhattarai S, Aryal S, Deo SK, Regmi B, Willcox M, Mishra SK. Antimicrobial resistance and biofilm production in uropathogens from renal disease patients admitted to Tribhuvan University Teaching Hospital, Nepal. Journal of Clinical Pharmacy and Therapeutics 2023. (
    13. Mishra SK, Muhammad Y, Willcox M. Candida auris: an emerging fast and furious 鈥渟uperbug鈥 with the highest level of concern. The Lancet Microbe 2023 April 26. ()
    14. Thapa S, Bhattarai A, Shah S, Chand S, Bagherieh S, Mirmosayyed O, Mishra SK. Diagnostic role of Tau proteins in Amylotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis. Acta Neurologica Scandinavica 2023. (doi.org/10.1155/2023/2791622)
    15. Tiwari A, Kurittu P, Heljanko V, Al-Mustapha AI, Johansson V, Thakali O, Mishra SK, Lehto KM, Lipponen A, Oikarinen S, Pitk盲nen T. Wastewater Surveillance of Antibiotic-Resistant bacterial pathogens: a Systematic Review. Frontiers in Microbiology 2022;13:4947. ()
    16. Basnet BB, Satyal D, Pandit R, Maharjan A, Karki R, Mishra SK, GC S, Basnet TB. Medical laboratory staff satisfaction and their perspective on the role of health institutions to combat COVID-19 pandemic. Journal of International Medical Research 2022 Jun;50(6):03000605221105356. ()
    17. Giri S, Ghimire A, Mishra A, Kuikel S, Tiwari A, Mishra SK. Prevalence of methicillin-resistant Staphylococcus aureus carriage among healthcare workers in South Asia in non-outbreak settings: a systematic review and meta-analysis. American Journal of Infection Control 2022. ()
    18. Bhattarai A, Dhakal G, Shah S, Subedi A, Sah SK, Mishra SK. Effect of preexisting asthma on the risk of ICU admission, intubation, and death from COVID-19: A systematic review and meta-analysis. Interdisciplinary Perspectives on Infectious Diseases 2022. ()听(Role: Supervision, literature review, study design, analysis, manuscript preparation, proof reading)
    19. Sartelli M, Labricciosa FM, Coccolini F, ...Mishra SK, 鈥., Catena F. It is time to define an organizational model for the prevention and management of infections along the surgical pathway: a worldwide cross-sectional survey. World Journal of Emergency Surgery 2022. ()
    20. Basnet BB, Satyal D, Pandit R, Basnet TB, Khattri S, Mishra SK. Knowledge, practice and psychological symptoms among medical laboratory staff during COVID-19 pandemic in Nepal: An online based survey. INQUIRY: The Journal of Health Care Organization, Provision, and Financing 2022; Mar 17;59:00469580221082783. (
    21. Willcox MDP, Afzal M, Alenezi H, Aziz MA, Enninful G, Kalaiselvan P, Khan M, Kuppusamy R, Masoudi S, Mishra SK, Ozkan J, Peguda HK, Rayamajhee B, Safvati A, Sara M, Sarwat S, Tummanapalli S, Urmi UL, Vijay AK, Yasir M. The COVID-19 pandemic at two years: Is this end in sight? Contact Lens Spectrum 2022; 37: 34-36, 38-40. ()
    22. Bhujel R, Mishra SK, Yadav SK, Bista KD, Parajuli K. Comparative study of Amsel鈥檚 criteria and Nugent scoring for diagnosis of bacterial vaginosis in a tertiary care hospital, Nepal. BMC Infectious Diseases 2021 Dec;21(1):1-6. ()
    23. Pandey R, Mishra SK, Shrestha A. Characterisation of ESKAPE pathogens with special reference to multidrug resistance and biofilm production in a Nepalese hospital. Infection and Drug Resistance 2021; 14: 2201鈥2212 ()
    24. Baidya S, Sharma S, Mishra SK, Kattel HP, Parajuli K, Sherchand JB. Biofilm formation by pathogens causing ventilator-associated pneumonia at intensive care units in a tertiary care hospital: an armor for refuge.听 BioMed Research International 2021 ()
    25. Karki R, Lamichhane S, Basnet BB, Dahal A, Awal BK, Mishra SK. In vitro antimicrobial synergy testing of extensively drug-resistant clinical isolates at an organ transplant center in Nepal. Infection and Drug Resistance 2021;14:1669-1677. ()
    26. Sapkota B, Yadav SK, Dhungana G, Ansari S, Mishra SK. Intestinal carriage of extended-spectrum-beta-lactamase (ESBL)-possessing Escherichia coli and Klebsiella species among Nepalese health science and non-health science students. Canadian Journal of Infectious Diseases and Microbiology 2021 ()
    27. Kharel S, Bist A, Mishra SK. Ventilator-Associated Pneumonia Among ICU patients in WHO Southeast Asian Region: A systematic review. PLOS ONE 2021 ()
    28. Shrestha S, Kharel S, Homagain S, Aryal R, Mishra SK. Prevalence of vancomycin-resistant enterococci in Asia - A systematic review and meta-analysis. Journal of Clinical Pharmacy and Therapeutics 2021 ()
    29. Yadav SK, Bhujel R, Mishra SK, Sharma S, Sherchand JB. Carbapenem resistance in non-fermentative Gram-negative bacilli isolated from intensive care unit patients of a referral hospital. Journal of Nepal Health Research Council 2021;听19(1), 55-61 () (Role: Supervision, study design, laboratory protocol preparation, analysis, manuscript preparation, proof reading)
    30. Sharma B, Yadav SK, Khanal A, Shakya B, Shrestha K, Aryal S, Kattel H, Parajuli K, Mishra SK. Fecal Carriage of Extended-Spectrum beta-Lactamase Producing Escherichia coli among Health Science Students. Journal of Nepal Health Research Council 2022; 20(01), 160-165.
    31. Rayamajhee B, Pokhrel A, Syangtan G, Lama B, Rawal LB, Mehata S, Mishra SK, Pokhrel R, Yadav UN. How well the Government of Nepal is responding to COVID-19? An experience from a resource limited country to confront unprecedented pandemic. Frontiers in Public Health 2021 (https://doi: 10.3389/fpubh.2021.597808)
    32. Mishra SK, Maharjan S, Yadav SK, Sharma S, Shah NP, Parajuli K, Sherchand JB. Bacteria on medical professionals鈥 white coats in a University Hospital. Canadian Journal of Infectious Diseases and Microbiology 2020 ()
    33. Yadav UN, Rayamajhee B, Mistry SK, Parsekar SS, Mishra SK. A syndemic perspective on the management of non-communicable diseases amid the COVID-19 pandemic in low- and middle-income countries. Frontiers in Public Health 2020;8:508 ()
    34. Yadav SK, Bhujel R, Mishra SK, Sharma S, Sherchand JB. Emergence of multi-drug resistant non-fermentative gram-negative bacterial infection in hospitalized patients in a tertiary care center of Nepal. BMC Research Notes 2020;13:319 ()
    35. Yadav SK,听Bhujel听R, Hamal P,听Mishra SK, Sharma S, Sherchand JB. Burden of Multidrug-Resistant听Acinetobacter baumannii听Infection in Hospitalized Patients in a Tertiary Care Hospital of Nepal.听Infection and Drug Resistance听2020;13:725-732
    36. Mandal DK, Sah SK,听Mishra SK, Sharma S, Kattel HP, Pandit S, Yadav PK, Laghu U, Lama R, Sah NP, Sherchand JB, Parajuli K, Bastola A, Pun SB, Rijal BP, Pokharel BM. Carriage of Extended-spectrum-b-lactamase- and AmpC-b-lactamase-producing Enterobacteriaceae (ESBL-PE) in healthy community and outpatient department (OPD) patients in Nepal.听Canadian Journal of Infectious Diseases and Medical Microbiology听2020
    37. Ansari S, Jha RK, Mishra SK, Tiwari BR, Asaad AM. Recent advances in Staphylococcus aureus infection: focus on vaccine development. Infection and Drug Resistance 2019; 12:1243-55.
    38. Sartelli M, Klugar Y, Ansaloni L, Carlet J, 鈥︹.. Mishra SK, 鈥︹︹atena F. A global declaration on appropriate use of antimicrobial agents across the surgical pathway. Surgical Infections 2017;18(8):846-53.
    39. Sartelli M, Labricciosa FM, Barbadora P, Pagani L,鈥.. Mishra SK, 鈥︹.Catena F. The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship鈥攔esults from an international cross-sectional survey. World Journal of Emergency Surgery 2017;12(34):1-11. DOI: 10.1186/s13017-017-0145-2.
    40. Sah R, Khadka S, Shah DS, Adhikari M, Shrestha N, Kattel HP, Sharma S, Mishra SK, Parajuli K, Sherchand JB, Shah NP, Pokharel BM, Rijal B. Vancomycin resistant Enterococcus faecalis causing diarrhea in renal transplant patient. International Educational Applied Scientific Journal 2017;2:9
    41. Khadka S, Sherchand JB, Pokhrel BM, Parajuli K, Mishra SK, Sharma S, Shah N, Kattel HP, Dhital S, Khatiwada S, Parajuli N, Pradhan M, Rijal BP. Isolation, speciation and antifungal susceptibility testing of Candida isolates from various clinical specimens at a tertiary care hospital, Nepal. BMC Research Notes 2017;10:218. DOI 10.1186/s13104-017-2547-3.
    42. Parajuli NP, Acharya SP, Mishra SK, Parajuli K, Rijal BP, Pokhrel BM. High burden of antimicrobial resistance among gram negative bacteria causing healthcare associated infections in a critical care unit of Nepal. Antimicrobial Resistance and Infection Control 2017; 6:67. DOI: 10.1186/s13756-017-0222-z
    43. Dhital S, Sherchand JB, Pokharel BM, Parajuli K, Mishra SK, Sharma S, Kattel HP, Khadka HP, Khadka S, Khatiwada S, Rijal B. Antimicrobial susceptibility pattern of Shigella spp. isolated from children under 5 years of age attending tertiary care hospitals, Nepal along with first finding of ESBL-production. BMC Research Notes 2017;10:192. DOI: 10.1186/s13104-017-2512-1
    44. Parajuli NP, Acharya SP, Dahal S, Singh JP, Mishra SK, Kattel HP, Rijal BP, Pokhrel BM. Epidemiology of device-associated infections in an intensive care unit of a teaching hospital in Nepal: A prospective surveillance study from a developing country. American Journal of Infection Control 2017. DOI:
    45. Dhital S, Sherchand JB, Pokhrel BM, Parajuli K, Shah N, Mishra SK, Sharma S, Kattel HP, Khadka S, Khatiwada S, Parajuli N, Rijal B. Molecular epidemiology of Rotavirus causing diarrhea among children less than five years of age visiting national level children hospitals, Nepal. BMC Pediatrics 2017.doi:10.1186/s12887-017-0858-0.
    46. Khadka S, Sherchand JB, Pokharel DB, Pokhrel BM, Mishra SK, Dhital S, Rijal BP. Clinicomycological Characterization of Superficial Mycoses from a Tertiary Care Hospital in Nepal. Dermatology Research and Practice 2016. doi:10.1155/2016/9509705 ()
    47. Moriguchi T, Kaneumi S, Takeda S, Enomoto K, Mishra SK, Miki T, Koshimizu U, Kitamura H, Kondo T. Ecrg4 contributes to the antiglioma immunosurveillance through type I interferon signaling. Oncoimmunology 2016.
    48. Khadka S, Regmi P, Giri S, Shah PK, Mishra SK. Identification of Candida species using CHROM agar. International Journal of Medicine and Biomedical Sciences 2016;1(3):10-3. (
    49. Pokhrel RH, Aung MS, Thapa B, Chaudhary R, Mishra SK, Kawaguchiya M, Urushibara N, Kobayashi N. Detection of ST772 Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus (Bengal Bay clone) and ST22 S. aureus isolates with a genetic variant of elastin binding protein in Nepal. New Microbes and New Infections 2016:11:20-7.
    50. Tada T, Miyoshi-Akiyama T, Shimada K, Dahal RK., Mishra SK, Ohara H, Kirikae T, Pokhrel BM. A Novel 6鈥-N-Aminoglycoside Acetyltransferase, AAC(6鈥)-Ial, from a Clinical Isolate of Serratia marcescens. Microbial Drug Resistance 2016 Mar;22(2):103-8. doi: 10.1089/mdr.2015.0126. Epub 2015 Aug 13.
    51. Mishra SK, Shrestha R, Rijal BP, Pokhrel BM. The bad, the ugly and the demon: A tale of extensively drug-resistant, extended-spectrum beta-lactamase- and metallo-beta-lactamase-producing superbugs associated with nosocomial pneumonia. Asian Pacific Journal of Tropical Disease 2015:5(1):71-6.
    52. Mishra SK, Basukala P, Basukala O, Parajuli K, Pokhrel BM, Rijal BP. Current Microbiology 2015;70:128-34.
    53. Shrestha B, Shrestha S, Mishra SK, Kattel HP, Tada T, Ohara H, Kirikae T, Rijal BP, Sherchand JB, Pokhrel BM. Phenotypic characterization of multidrug-resistant Escherichia coli with special reference to extended-spectrum-beta-lactamases and metallo-beta-lactamases in a tertiary care center. Journal of Nepal Medical Association 2015 Apr-Jun;53(198):89-95.
    54. Mishra SK, Kattel H, Pokhrel BM, Rijal BP. High prevalence of extended-spectrum beta-lactamase-producing respiratory bacterial pathogens in a Nepalese University Hospital: A vexatious problem. Annals of Clinical Chemistry and Laboratory Medicine 2015:1(2):8-14.
    55. Sah MK, Mishra SK, Ohora H, Kirikae T, Sherchan JB, Rijal BP, Pokhrel BM. Nosocomial bacterial infection and antimicrobial resistant pattern in a tertiary care hospital in Nepal. Journal of Institute of Medicine 2014:35(3):38-48.
    56. Prajapati J, Regmi BM, Shrestha TM, Bharti L, Basyal D, Mishra SK, Gyawali R. Analgesic and Antibacterial Activity of Methanolic Extract of Smilax lanceifolia. International Journal of Pharmaceutical and Biological Archives 2014;5(3):79-83.
    57. Tada T, Miyoshi-Akiyama T, Dahal RK, Mishra SK, Shimada K, Ohara H, Kirikae T, Pokhrel BM. Identification of a Novel 6鈥-N-Aminoglycoside Acetyltransferase, AAC(6鈥)-Iak, from a Multidrug-Resistant Clinical Isolate of Stenotrophomonas maltophilia. Antimicrobial Agents and Chemotherapy 2014 Aug 4. pii: AAC.03354-14.
    58. Mishra SK, Awal BK, Kattel HP, Acharya J, Gyawali P, Bhatt CP, Shah NP, Parajuli K, Rijal BP, Pokhrel BM. Drug Resistant Bacteria are Growing Menace in a University Hospital in Nepal. American Journal of Epidemiology and Infectious Disease 2014;2(1):19-23.
    59. Ohara H, Pokhrel BM, Dahal RK, Mishra SK, Kattel HP, Shrestha DL, Haneishi y, Sherchand JB. Fact-finding survey of nosocomial infection control in hospitals in Kathmandu, Nepal鈥擜 basis for improvement. Tropical Medicine and Health 2013; doi: 10.2149/tmh.2013-03.
    60. , , , , , , , . Dissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal. International Journal of Antimicrobial agents 2013: doi: 10.1016/j.ijantimicag.2013.06.014.
    61. Mishra SK, Rijal BP, Pokhrel BM. Emerging threat of multidrug resistant bugs 鈥 Acinetobacter calcoaceticus baumannii complex and Methicillin resistant Staphylococcus aureus. BMC Research Notes 2013: 6:98. (Highly accessed article)
    62. Ansari S, Sherchand JB, Rijal BP, Parajuli K, Mishra SK, Dahal RK, Shrestha S, Tandukar S, Chaudhary R, Kattel HP, Basnet A, Pokhrel BM. Characterisation of rotavirus causing acute diarrhea in children in Kathmandu, Nepal, showing the dominance of serotype G12. Journal of Medical Microbiology 2012; 62:114-20.
    63. Ansari S, Sherchand JB, Parajuli KP, Paudyal BM, Adhikari RP, Shrestha S, Mishra SK, Dahal RK, Tandukar S, Khadka R, Shrestha R, Baral SK, Pokhrel BM. Pattern of Acute Parasitic Diarrhea in Children Under Five Years of Age in Kathmandu, Nepal. Open Journal of Medical Microbiology 2012;2(3),doi:10.4236/ojmm.2012.23014.
    64. Mishra SK, Kattel HP, Acharya J, Shah NP, Shah AS, Sherchand JB, Rijal BP, Pokhrel BM. Recent trend of bacterial etiology of lower respiratory tract infections in a tertiary care centre of Nepal. International Journal of Infection and Microbiology 2012:1(1);3-8. doi:
    65. Subedi A, Amatya MP, Shrestha TM, Mishra SK, Pokhrel BM. Antioxidant and antibacterial activity of methanolic extract of Machilus odoratissima. Kathmandu University Journal of Science, Engineering and Technology 2012;8(1):73-80.
    66. Mishra SK, Acharya J, Kattel HP, Koirala J, Rijal BP, Pokhrel BM. Metallo-beta-lactamase producing gram-negative bacterial isolates. Journal of Nepal Health Research Council 2012 Sep;10(22):208-13.
    67. Ansari S, Sherchand JB, Parajuli K, Mishra SK, Dahal RK, Shrestha S, Tandukar S, Pokhrel BM. Journal of Nepal Health Research Council 2012 Sep;10(22):218-23.
    68. Marhatta SB, Gautam S, Dhital S, Pote N, Jha AK, Mahato R, Mishra S, Poudel BH, Ramasoota P, Kaewkungwal J, Singhasivanon P. katG (SER 315 THR) gene mutation in isoniazid resistant Mycobacterium tuberculosis. Kathmandu University Medical Journal 2011;33(1):19-23.
    69. Pokhrel BM, Karmacharya R, Mishra SK, Koirala J. Distribution of Antibody Titer against Salmonella enterica among Healthy Individuals in Nepal. Annals of Clinical Microbiology and Antimicrobials 2009;8:1doi:10.1186/1476-0711-8-1. .
    70. Pokharel BM, Koirala J, Dahal R, Mishra SK, Khadga PK, Tuladhar NR. Multidrug-resistant and extended-spectrum beta-lactamase (ESBL)-producing Salmonella enterica (serotypes Typhi and Paratyphi A) from blood isolates in Nepal: Surveillance of resistance and a search for newer alternatives. International Journal of Infectious Diseases 2006;10:434-8.
    71. Lakhey M, Bhatta CP, Mishra S. Diagnosis of Tubercular Lymphadenopathy by Fine Needle Aspiration Cytology, Acid-Fast Staining and Mantoux Test. Journal of Nepal Medical Association 2009;48:230-3.
    72. Mishra SK, Shah JP, Shrestha R, Lakhey M. Emergence of nalidixic acid resistant Salmonella: A confounding scene in antibiotic armamentarium. Journal of Nepal Association for Medical Sciences 2008;9(1);64-6.
    73. Pokhrel BM, Koirala J, Mishra SK, Dahal R, Khadga PK, Tuladhar NR. Multidrug resistance and extended spectrum beta lactamase producing strains causing lower respiratory tract and urinary tract infection. Journal of Institute of Medicine 2006;28(3):19-27.
    74. Tamang MD, Sharma N, Makaju RK, Sharma AN, Koju R, Nepali N, Mishra SK. An outbreak of El Tor Cholera in Kavre district, Nepal. Kathmandu University Medical Journal 2005;3(2):138-42.

  • Reports and Book Chapters

    • Practical Medical Parasitology (Vidyarthi Pustak Bhandar, Nepal) (2014)

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    Digital Book Chapter (International Publication):

    • Mishra SK, Hui A, Willcox M. Biofilm and medical device-associated infections. In Global Infection Prevention and Management in Healthcare, 1st ed.; Advanced Meetings Solutions: Carrollton, TX, USA, 2024; Volume 2, pp. 168-180. (Available at )